学士（北京大学生物技术系）；博士（香港大学医学院生物化学系）

研究员，协和、北医、首医、临研所硕导

科技中心基础研究部副主任；仪器平台负责人

wzai_163pass@163.com

个人简介

继往研究包括黄病毒（CSFV、ZIKV）及冠状病毒(SARS-CoV、MERS-CoV、SARS-CoV-2)入侵机制、肺纤维化病理机制及新疗法等。现与本院呼吸中心开展合作，探索呼吸道病毒感染导致肺及肺外损伤病理机制。以第一或通讯作者在Lancet Infectious Diseases、Cell Discovery、ACS Nano、iScience、Development等杂志发表SCI论文23篇，先后主持国自然青年项目、医科院重大协同创新项目子课题、国自然面上项目、国家重点研发计划子课题等课题7项。

研究方向

基于流感病毒感染小鼠模型、假病毒模型等研究：

1. 流感病毒、新冠病毒入侵机制；

2. 病毒经肺向肺外脏器播散机制；

2. 肺及肺外脏器损伤机制及靶点发掘。

近五年发表文章

1. W Zuo#, D He#, C Liang#, S Du, Z Hua, Q Nie, X Zhou, M Yang, H Tan, J Xu, Y Yu, Y Zhan, Y Zhang, X Gu, W Zhu, H Zhang, H Li, W Sun, M Sun, X Liu, L Liu, C Cao, R Li, J Li, Y Zhang, Y Zhang, J Guo, L Zhao, CP Zhang, H Liu, S Wang, F Xiao, Y Wang, Z Wang*, H Li*, B Cao*, The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China, Lancet Infectious Diseases, 2024 Apr 22; S1473-3099(24)00171-3. (IF 36.4)

2. Peipei Liu#，Shengnan Yang#，Xuecheng Shao, Zai Wang*，Huaping Dai*，Chen Wang*, Mesenchymal stem cells-derived exosomes alleviate acute lung injury by inhibiting alveolar macrophage pyroptosis, Stem Cells Translational Medicine, 2024 Apr 15; 13(4):371-386. doi: 10.1093/stcltm/szad094. (IF 5.4)

3. Zhan Hua#, Shan Wu#, Yulian Zhang#, Xiuhong Wang, Ju Cui, Yunxuan Li, Chengcheng Yang, Min Zhai, Bo Deng, Bin Yu, Jian-Dong Huang, Zai Wang* and Jianjun Zhou*, Targeted IFNγ induction by a genetically engineered Salmonella typhimurium is the key to the liver metastasis inhibition in a mouse model of pancreatic neuroendocrine tumor, Frontiers in Medicine, 10:1284120 (IF 3.1)

4. Pengfei Pei#, Long Chen*, Ruru Fan, Xi-Rui Zhou, Shan Feng, Hangrui Liu, Quanqiang Guo, Huiwei Yin, Qiang Zhang, Fude Sun, Liang Peng, Peng Wei, Chengzhi He, Renzhong Qiao, Zai Wang*, and Shi-Zhong Luo*, Computer-Aided Design of Lasso-like Self Assembling Anticancer Peptides with Multiple Functions for Targeted Self-Delivery and Cancer Treatments, ACS Nano, 2022, 16:13783–13799 (IF 18.0)

5. Shengnan Yang #, Peipei Liu #, Tingting Gao #, Dingyun Song, Xinyu Zhao, Yupeng Li, Jun Wu, Liu Wang, Zai Wang*, Jie Hao*, Chen Wang*, Huaping Dai*, Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes, Stem Cell Research &Therapy, 2022, 13:163. (IF 6.8)

6. Z. Wang#, T. Deng#, Y. Zhang#, W. Niu, Q. Nie, S. Yang, P. Liu, P. Pei, L. Chen, H. Li*, B. Cao*, ACE2 can act as the secondary receptor in the FcgammaR-dependent ADE of SARS-CoV-2 infection, iScience, 2022, 25:103720. (IF 5.4)

7. Peipei Liu#, Shengnan Yang#, Zai Wang*, Huaping Dai*, Chen Wang*, Feasibility and Mechanism Analysis of Shenfu Injection in the Treatment of Idiopathic Pulmonary Fibrosis, Front Pharmacol, 2021, 12:670146. (IF 5.8)

8. PG. Wang, DJ. Tang, Z. Hua, Z. Wang*, J. An*, Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation, Cell Discov, 2020, 6:71. (IF 10.8)

欢迎加入团队：

1. 对科研有较强的兴趣；

2. 勤奋努力；

3. 良好的沟通能力。